INDUCE Oi-9 Bioimplants: The Future of Bone Regeneration

When it comes to bone regeneration, oral surgeons are always on the lookout for the most advanced and reliable materials to enhance their likelihood of a successful outcome for their patient. INDUCE Oi-9 Bioimplants offer an innovative solution for regenerative procedures, unlocking the body’s innate healing capabilities by leveraging bioavailability of natural growth factors in the bone. Designed to support diverse clinical workflows, these advanced allograft products provide a powerful tool for oral and maxillofacial surgeons treating a range of bony defects.

Unlocking Natural Growth Factors

INDUCE Oi-9 Bioimplants are developed using the proprietary NMP® (Natural Matrix Protein®) Process, a multi-step method that unlocks growth factors embedded in the bone matrix, enhancing their bioavailability. Once unlocked, these growth factors become more accessible at the grafting site—supporting the body’s natural healing response and encouraging effective tissue repair and bone regeneration.

The NMP Process unlocks a variety of critical growth factors naturally present in the bone, including Bone Morphogenic Proteins (BMPs) and other essential molecules. Among these are BMP-2, BMP-7, BMP-9, TGF-ϐ1, PDGF, VEGF, and IGF-2, all of which are known to work synergistically to facilitate the complex cascade of successful bone regeneration. Research shows that these growth factors support the healing process by encouraging bone formation and tissue repair.

Versatility and Easy Handling for Clinical Use

INDUCE Oi-9 Bioimplants are available in two forms to accommodate a variety of clinical needs: FiberMatrix and Micro Particulates. Both forms are processed from human cortical bone and are optimized for different surgical procedures from filling larger defects or finer precision and detailed work.

One of the standout features of INDUCE Oi-9 Bioimplants is their superior handling and flexibility. Upon hydration, the material becomes a moldable, easy-to-place putty, making it highly versatile. Clinicians can use the product alone or combined with other graft materials, depending on the specific requirements of the procedure. This adaptability ensures seamless integration into clinical workflows, enhancing efficiency during surgery.

Proven Results in Bone Regeneration†

Achieving both quality and quantity of bone regeneration is critical for the long-term success of dental implants and other oral surgeries. In animal studies, Induce Oi-9 demonstrated greater bone formation, outperforming standard bone grafting materials. INDUCE Oi-9 Bioimplants was also shown to deliver strong outcomes in both bone quality and quantity compared to other bone regeneration materials, such as recombinant human BMP-2 (rhBMP-2).

INDUCE Oi-9 naturally supports the restoration of healthy bone structure. The rich array of growth factors, including BMPs, TGF-β1, and VEGF, work synergistically to promote the development of new bone and vascular tissue, making it an ideal solution for complex regenerative procedures.

Ideal for a Variety of Clinical Applications

INDUCE Oi-9 Bioimplants are suitable for a wide range of bone defect procedures. These include:

• Periodontal Defects and Furcation Defects: Addressing bone loss associated with periodontal disease.
• Ridge Augmentation: Regenerating bone in the alveolar ridge, which is essential for supporting implants and improving aesthetics.
• Peri-Implantitis: Treating bone loss around implants to help save failing implants.
• Sinus Lift: Supporting sinus elevation procedures to create sufficient bone for implants in the posterior maxilla.
• Socket Preservation: Protecting and regenerating the bone following tooth extraction.

Safe, Convenient, and Shelf-Stable

One of the most practical advantages of INDUCE Oi-9 are their ease of use and convenience. These products are terminally sterilized, freeze-dried, and can be stored at ambient temperatures with 5-year shelf-life, which makes them a practical choice for busy surgical practices. Clinicians can rehydrate the product at the time of use with whole blood, lactated Ringer’s solution, or saline, depending on their preference. This flexibility in rehydration methods makes INDUCE Oi-9 Bioimplants easy to incorporate into various procedural settings.

INDUCE Oi-9 Bioimplants represent a breakthrough in bone regeneration technology. With their advanced processing, superior bioavailability of growth factors, and versatile clinical applications, these bioimplants are an invaluable tool for oral surgeons and periodontists aiming to achieve optimal healing and successful outcomes in bone regeneration procedures.

For more information or to place an order, visit INDUCE Oi-9 | ACE SOUTHERN or call 800-624-5926 and speak to our experienced customer service team who is available to answer your questions Monday-Friday, 8am to 8pm.

† Kohen Y., et al. Evaluation of the Natural Matrix Protein (NMP®) bone allograft in vitro and in vivo. JBMR 38:S1 p342 (2023), and MKT-005 Rev.1, Induce Biologics 2022, company internal document.